A brief discussion on Ibrutinib

Belonging to the kinase inhibitor class of drugs, Ibrutinib is used for treating Mantle cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and Waldenström’s macroglobulinemia. They are available in tablet forms and capable of destroying the cancer cells by blocking some of the essential enzymes that are required for the growth of cells.

How is Ibrutinib given?

Depending on your current health condition and stage of cancer, the doctor will prescribe a particular dosage for this drug. This Ibrutinib tablet is consumed orally by swallowing with 8 ounces water. It is strictly recommended not to chew, open, or crush it. If you miss a certain dose, contact your healthcare professional. In any case, try to keep up with the normal routine and don’t double the dose under any circumstances. Note that this is not a chemotherapy drug. It is used to conduct targeted drug therapy for curing cancer. In some cases, it is also prescribed to patients who had a stem cell transplant. 

Dosage and Usage 

Ibrutinib dose will vary according to the health condition of the patient, stage, and type of cancer. For oral administration, Ibrutinib 140 mg and 70mg are the typically prescribed doses. Usually, high doses like 420mg and 560mg may also be prescribed, but the former-mentioned amount is safe for avoiding unbearable toxicity in the patient body. They can be prescribed as single agents or in combination with other drugs. Usually, one to four Imbruvica tablets are consumed each day. It is advised to keep it out of reach of children. 

For Marginal zone lymphoma, Ibrutinib is applicable to the adult patient who has previously received at least a single anti-CD20 therapy. Basing on the overall response from the body, your doctor may grant accelerated approval. 

Precautionary measures to be taken while taking Ibrutinib tablet

1. A complete health diagnosis will take place before your doctors prescribed this drug to determine your overall health condition and whether the body is capable of tolerating the side effects. 
2. It is also imperative to mention the current medications that you are on to avoid harmful reactions later. 
3. It is mandatory for the patient to drink two to three quarts of fluid regularly. 
4. Direct sun exposure must also be avoided if you are on Ibrutinib because the drug gets active under such conditions and may cause skin burn. 
5. Alcoholic beverages and smoking are also prohibited. 
6. One should get plenty of rest and maintain a healthy diet during this time. 
7. All types of vitamin supplements and herbal remedies are to be avoided while you are undergoing this drug therapy. 
8. In case you are pregnant or plan to get pregnant, tell your doctor because Ibrutinib can be absorbed through the skin and lungs, which may harm the fetus. Your doctor will also recommend avoiding breastfeeding during this period. 
9. Without the doctor’s approval, the patient must not take any vaccination or immunization shots. 
10. There are certain food items that must be avoided strictly if you are taking this medicine- for instance, grapefruit and Seville oranges contain strong inhibitors of CYP3A and must not be consumed by the patient. They can increase the amount of Ibrutinib in your blood and cause harmful reactions. 

Ibrutinib Side effects

These are some of the side effects that are seen in patients but are reversible and cease to exist after the treatment is over-

• Decreased number of platelets and RBC
• Upper respiratory tract infection 
• Unusual bruising and bleeding
• Nausea and vomiting 
• Black stool and bloody urine 
• Dizziness and fatigue 
• Diarrhea 
• Decreased appetite and loss of weight 
• Increased blood pressure

In case the health condition gets worse or unmanageable, contact your doctor immediately. Under such circumstances, certain drugs can be prescribed to deal with the side effects or alterations of doses are recommended. 

Conclusion

The Imbruvica 140mg or Ibrutinib 140 mg price is quite high. Usually, Imbruvica cost for 70mg dosage is $13,546. It is advised to have medical insurance to cover the high expenses for treatment. Regular blood tests are also conducted by the doctor to check the progress of treatment. Store it at room temperature, preferably 15 to 30 degree Celsius, away from direct source of light and high humidity. 

FAQ

What is the brand name of Ibrutinib? 
Imbruvica is the brand name of Ibrutinib. 

What are the uses of Ibrutinib? 
Ibrutinib is used for the treatment of:

• Mantle cell lymphoma
• Chronic lymphocytic leukemia
• Waldenström's macroglobulinemia

What are the most commonly reported side effects due to Ibrutinib? 
The most commonly reported side effects due to Ibrutinib include pneumonia, sinusitis, skin infection, upper respiratory tract infection, low neutrophil count, headache, low platelet counts, bleeding, bruising, rash, inflammation of mouth and lips, diarrhea, vomiting, nausea, constipation, joint pain, musculoskeletal pain, fever, edema and muscle spasms. 

How much water should I drink with Ibrutinib?
During treatment with ibrutinib, drink at least 2 to 3 quarts of fluid every 24 hours, unless you are directed otherwise. Hands should often be washed after taking every single dose of ibrutinib.

Does Ibrutinib lower the immune system?
Newer existing targeted BTK inhibitors such as ibrutinib and acalabrutinib usually do not suppress the bone marrow and may actually improve certain aspects of your immune system. 

Do you take Ibrutinib through food?
Ibrutinib can be taken either with or without food. Swallow the tablets or capsules whole through water; avoid opening, crushing or chewing them. 

Can I drink alcohol while on Ibrutinib?
Generally, consuming alcoholic beverages need to be eliminated or avoided while taking the medication ibrutinib. Good nutrition must be maintained and get plenty of rest. Avoid receiving any immunization or vaccination without your healthcare provider's approval.
 

Disclaimer: The afore-mentioned content is only for informative purpose. We don’t claim the effectiveness of the drug.
 

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